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Related Concept Videos

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Related Experiment Video

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Minimally Invasive Transverse Aortic Constriction in Mice
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New insights on tuberculous aortitis.

Laure Delaval1, Tiphaine Goulenok1, Paul Achouh2

  • 1Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Paris, France.

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Summary

Tuberculous aortitis (TA) is rare but treatable. Combined therapy including anti-tuberculosis drugs, surgery, and steroids led to clinical improvement and no deaths in 11 patients.

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Vascular Surgery

Background:

  • Tuberculosis (TB) is a rare cause of aortitis.
  • Tuberculous aortitis (TA) presents unique diagnostic and therapeutic challenges.

Purpose of the Study:

  • To describe the clinical characteristics, treatment, and outcomes of patients with tuberculous aortitis.
  • To evaluate the efficacy of a combined treatment strategy for TA.

Main Methods:

  • A multicenter review of 11 patients diagnosed with TA between 2003 and 2015.
  • Data collected included demographics, medical history, laboratory and imaging findings, pathology, treatment, and follow-up.
  • TA diagnosis required concurrent diagnosis of aortitis and active tuberculosis.

Main Results:

  • Eleven patients (8 women, median age 44.6 years) with active TB and TA were identified.
  • Aortic pseudoaneurysm was the most common finding, followed by inflammatory aortic stenosis.
  • All patients received antituberculosis therapy (6-12 months), 8 underwent surgery, and 7 received steroids; all showed clinical improvement with no mortality at 4-year median follow-up.

Conclusions:

  • Tuberculous aortitis can manifest as aneurysms or isolated inflammatory aortic stenosis.
  • A combined treatment approach involving antituberculosis therapy, surgery, and steroids is effective.
  • This strategy leads to significant clinical improvement and survival in patients with TA.