Related Experiment Video
Updated: Mar 6, 2026

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
Published on: July 8, 2025
Harnessing a pyrimidine based molecular switch to construct reversible test strips for F-/AcO- with respect to Al3+:
Arghyadeep Bhattacharyya1, Soumen Ghosh1, Subhash Chandra Makhal1
1Department of Chemistry, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India.
Abstract:
We report novel compound 4-nitro-2-((pyrimidin-2-ylamino) methyl) phenol (1) synthesized by the condensation of 5-nitro salicylaldehyde with 2-amino pyridine. Compound 1 serves as a dual signalling chromogenic receptor for F-/AcO- and Al3+ ions. The chromogenic response of 1 towards the aforementioned analytes is reversible with respect to either Al3+/X (=F/AcO)- or X(F/AcO)-/Al3+. The limit of detection of 1 for F- and AcO- are 1.0025×10-7M and 0.79×10-7M, respectively. The optical switching has been rationalized on the basis of UV-Vis titrations and 1H NMR titrations respectively. The optical switching has been successfully use by constructing reversible paper strips for detecting Al3+ as well as F-/AcO-.
More Related Videos
Related Concept Videos
Amines to Sulfonamides: The Hinsberg Test
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
Acid Halides to Amides: Aminolysis
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...

