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Updated: Jul 6, 2026

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Published on: February 6, 2019

Direct Spirocyclization of Tryptamines with Dearomatized Phenols Enables Catalyst-Free Access to C3-Spirocyclic

Rima Samanta1, Rina Mahato1, Vigneshwaran V2

  • 1Department ofChemistry, Indian Institute ofTechnology Delhi, New Delhi 110016, India.

Organic Letters
|July 4, 2026
PubMed
Summary

This study introduces a novel fluorinated alcohol method for synthesizing spirocyclic indolenines from tryptamines. This catalyst-free approach efficiently creates complex molecules with broad applicability and high yields.

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