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Related Experiment Video

Updated: Mar 6, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Sarcopenia correlates with systemic inflammation in COPD.

Min Kwang Byun¹, Eun Na Cho¹, Joon Chang²

¹Division of Pulmonology, Department of Internal Medicine, Gangnam Severance Hospital.

International Journal of Chronic Obstructive Pulmonary Disease

|March 4, 2017

Summary

Sarcopenia, characterized by muscle wasting, is common in COPD patients, linked to inflammation and reduced exercise capacity. Systemic inflammation may drive sarcopenia in this population.

Keywords:

COPD handgrip strength muscle wasting sarcopenia systemic inflammation

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Area of Science:

Pulmonary Medicine
Geriatrics
Inflammology

Background:

Chronic Obstructive Pulmonary Disease (COPD) is frequently accompanied by muscle wasting and chronic inflammation.
Systemic inflammation in COPD patients correlates with a faster decline in lung function.

Purpose of the Study:

To investigate the prevalence of sarcopenia in stable COPD patients.
To examine the relationship between sarcopenia and systemic inflammation markers in COPD.

Main Methods:

A cross-sectional study involving 80 stable COPD patients (age ≥40).
Muscle strength (handgrip strength - HGS) and muscle mass (skeletal muscle mass index - SMMI) were measured.
Circulating inflammatory biomarkers (IL-6, high-sensitivity TNFα - hsTNFα) were quantified.

Main Results:

Sarcopenia was identified in 25% of patients, associated with older age, lower BMI, and comorbidities.
Sarcopenic patients exhibited greater dyspnea (mMRC scores) and reduced exercise tolerance (6-minute walk distance).
Both HGS and SMMI showed significant inverse correlations with IL-6 and hsTNFα levels.

Conclusions:

Sarcopenia is highly prevalent in stable COPD and linked to increased symptom severity and decreased exercise capacity.
Systemic inflammation is a significant factor contributing to sarcopenia development in COPD patients.