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Small-Molecule RORγt Antagonists: One Stone Kills Two Birds

Chao Zhong1, Jinfang Zhu2

  • 1Molecular and Cellular Immunoregulation Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

Trends in Immunology
|March 5, 2017
PubMed
Summary

RORγt antagonists, used to suppress T helper 17 cells, also reduce self-reactive T cells in the thymus. This finding suggests potential new strategies for preventing autoimmune diseases.

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