Related Experiment Video
Updated: Mar 6, 2026

12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
10.9K
Healthy infant with a blistering rash
Paul H Fenton1, Matthew J Landherr2, Megan H Noe3
1Carver College of Medicine, Iowa City, IA, USA.
The Journal of Family Practice
|March 5, 2017
Summary
A child presented with a distinctive rash. Despite parental reports of no environmental exposures or contact with similar cases, the rash distribution provided key diagnostic clues.
Area of Science:
- Pediatrics
- Dermatology
Background:
- Atypical presentations of childhood rashes can pose diagnostic challenges.
- Identifying the etiology of pediatric rashes is crucial for appropriate management and preventing complications.
Purpose of the Study:
- To highlight the diagnostic significance of rash distribution in pediatric cases.
- To emphasize the importance of thorough clinical examination in the absence of clear exposure history.
Main Methods:
- Case report detailing a pediatric patient with an unusual rash.
- Clinical observation focusing on the morphological characteristics and distribution pattern of the rash.
- Review of differential diagnoses based on clinical findings.
Main Results:
- The specific pattern of the rash distribution was the primary indicator for the diagnosis.
- Exclusion of common environmental or contagious causes based on patient history.
Conclusions:
- The distribution of a rash can be a highly informative diagnostic tool in pediatric dermatology.
- A detailed examination is paramount, even when exposure history is negative.
Related Concept Videos
Development of Immunocompetence
1.1K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
Skin Diseases and Disorders
5.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.9K
Changes in Skin Color: Clinical Perspectives
4.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.0K
Skin Cancer
6.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.4K
Endocarditis II: Clinical Features of Infective Endocarditis
662
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
662
Decreased Body Temperature
1.1K
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.1K

