Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.5K
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

1.4K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.4K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

50.1K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
50.1K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.7K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.1K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.1K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

7.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adherence to Hepatocellular Carcinoma Surveillance Guidelines Among People with HIV and Chronic HBV Infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Protein-dependent CD4<sup>+</sup> T cell specialization and CD8<sup>+</sup> T cell-driven IL-2 production in HIV.

iScience·2026
Same author

RNA promotes synapsin phase separation providing a platform for local translation.

bioRxiv : the preprint server for biology·2026
Same author

Do AI-based contouring algorithms influence physicians in the online adaptive radiotherapy of patients with bladder cancer?

Technical innovations & patient support in radiation oncology·2026
Same author

A Prospective Incidence Study on Sexually Transmitted Infections and HIV in Men Who Have Sex With Men, With or Without Use of Pre-exposure Prophylaxis.

Open forum infectious diseases·2026
Same author

Quantifying the Renal Impact of [<sup>177</sup>Lu]Lu-PSMA-617: A Longitudinal Analysis of Real-World Data from the LUMEN Registry.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

Efficacy of Honey Combined with Cryotherapy in the Prevention and Management of Radiation-Induced Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Head and Neck Cancer.

Oncology research and treatment·2026
Same journal

Three therapeutic modalities for advanced ovarian cancer: real world data from a certified oncological center.

Oncology research and treatment·2026
Same journal

Real world experiences in the treatment of immune thrombocytopenia over a two-year period.

Oncology research and treatment·2026
Same journal

Safety and preliminary activity of neoadjuvant trastuzumab deruxtecan (T-DXd) plus 5-fluorouracil and folinic acid for HER2-positive, resectable esophagogastric adenocarcinoma: Results from the safety run-in cohort of the phase Ib/II UCCL-AIO-STO0124-IKF072 NeoART trial.

Oncology research and treatment·2026
Same journal

Genitourinary Oncology Highlights from the European Society for Medical Oncology Annual Meeting 2025: Advances in Renal Cell Carcinoma and Muscle-invasive Bladder Cancer.

Oncology research and treatment·2026
Same journal

The Role of Regulatory Policies in Shaping Outpatient Cancer Treatment in Germany: A Comparative Perspective.

Oncology research and treatment·2026
See all related articles

Related Experiment Video

Updated: Mar 6, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

13.1K

HIV-Associated Kaposi's Sarcoma.

Christian Hoffmann, Michael Sabranski, Stefan Esser

    Oncology Research and Treatment
    |March 6, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Combination antiretroviral therapy (cART) significantly reduces Kaposi's sarcoma (KS) risk in HIV patients. Effective cART often leads to KS stabilization or resolution, making it a rarity.

    More Related Videos

    An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
    09:53

    An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

    Published on: August 25, 2017

    9.4K
    Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus
    07:10

    Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus

    Published on: August 15, 2025

    905

    Related Experiment Videos

    Last Updated: Mar 6, 2026

    Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
    07:02

    Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

    Published on: September 14, 2010

    13.1K
    An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
    09:53

    An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

    Published on: August 25, 2017

    9.4K
    Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus
    07:10

    Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus

    Published on: August 15, 2025

    905

    Area of Science:

    • Oncology
    • Infectious Diseases
    • Immunology

    Background:

    • Kaposi's sarcoma (KS) remains a prevalent malignancy in individuals with human immunodeficiency virus (HIV) infection.
    • Combination antiretroviral therapy (cART) demonstrates a protective effect against KS development, even in immunocompetent HIV patients.

    Purpose of the Study:

    • To review the impact of cART on the incidence and progression of KS in HIV-infected individuals.
    • To discuss current and emerging therapeutic strategies for HIV-associated KS.

    Main Methods:

    • Review of large randomized clinical trials and clinical observations regarding cART and KS.
    • Analysis of KS pathogenesis and potential novel treatment targets.

    Main Results:

    • Sufficient cART has rendered KS a rare condition in HIV patients.
    • Initiation of cART typically results in KS lesion stabilization or complete resolution, linked to reduced HIV viremia and immune reconstitution.
    • Advanced or rapidly progressive KS may necessitate cART combined with chemotherapy, particularly in immune reconstitution syndrome.

    Conclusions:

    • cART is highly effective in preventing and managing HIV-associated Kaposi's sarcoma.
    • Future therapies targeting KS pathogenesis, including antiviral agents, cytokines, and anti-angiogenic drugs, show promise.