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Sevoflurane downregulates IGF‑1 via microRNA‑98

Jue Jiang1, Zhifeng Chen1, Yaqiong Yang1

  • 1Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.

Molecular Medicine Reports
|March 6, 2017
PubMed
Summary

Sevoflurane anesthesia reduces insulin-like growth factor-1 (IGF-1) neuroprotection by increasing microRNA-98. Inhibiting microRNA-98 can restore IGF-1 levels, suggesting a novel therapeutic target.

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