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Updated: Mar 6, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Is there a role for high resolution manometry in GERD diagnosis?
Salvatore Tolone1, Edoardo Savarino2, Ludovico Docimo3
1Division of Surgery, Department of Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy - salvatore.tolone@unina2.it.
High-resolution manometry (HRM) enhances gastroesophageal reflux disease (GERD) diagnosis by assessing esophageal motility and esophagogastric junction function. Combined with impedance, HRM offers a comprehensive evaluation for pathological reflux.
Area of Science:
- Gastroenterology
- Digestive Physiology
Background:
- Gastroesophageal reflux disease (GERD) diagnosis often requires instrumental tests for refractory cases.
- Esophageal manometry is standard for motility but limited for GERD diagnosis.
Purpose of the Study:
- To review advancements in high-resolution manometry (HRM) for GERD evaluation.
- To explore HRM's potential in diagnosing pathological reflux.
Main Methods:
- High-resolution manometry (HRM) for esophageal motility and esophagogastric junction (EGJ) assessment.
- Evaluation of EGJ contraction integral and transient lower esophageal relaxations.
- Provocative tests and impedance measurements integrated with HRM.
Main Results:
- HRM provides more accurate esophageal motility evaluations.
- New metrics assess EGJ antireflux barrier function and transient relaxations.
- Impedance-HRM detects reflux and measures baseline impedance for mucosal integrity.
Conclusions:
- HRM offers improved diagnostic capabilities for GERD.
- Integrated impedance-HRM shows promise for assessing pathological reflux and mucosal integrity.
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