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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

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Diagnostic Importance of Platelet in Patients with Acute Coronary Syndrome Admitted in Mymensingh Medical College

M A Islam1, N I Siddiqui, M S Begum

  • 1Dr Md Azharul Islam, FCPS Part-II Examinee, Department of Medicine, Mymensingh Medical College Hospital, Mymensingh, Bangladesh;

Mymensingh Medical Journal : MMJ
|March 7, 2017
PubMed

Insights

Platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) were significantly elevated in acute coronary syndrome (ACS) patients compared to healthy controls. These findings suggest larger platelets may indicate higher risk for coronary events.

Area of Science:

  • Cardiology
  • Hematology
  • Clinical Diagnostics

Background:

  • Acute coronary syndrome (ACS) is a major cause of cardiovascular mortality.
  • Platelets play a critical role in atherothrombosis, the underlying mechanism of ACS.
  • Routine hematological parameters may offer insights into ACS pathophysiology.

Purpose of the Study:

  • To investigate the relationship between platelet indices and acute coronary syndrome.
  • To compare platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) in ACS patients versus healthy controls.

Main Methods:

  • A cross-sectional descriptive study involving 50 ACS patients and 50 age/sex-matched healthy controls.
  • Diagnosis of ACS based on clinical history, ECG, and cardiac biomarkers.
  • Platelet parameters (PC, MPV, PDW) measured using an automated hematological analyzer.

Main Results:

  • All measured platelet indices (PC, MPV, PDW) were significantly higher in ACS patients (mean PC: 352.2×10⁹/L, MPV: 13.9fL, PDW: 15.6fL) compared to controls (mean PC: 256.2×10⁹/L, MPV: 8.1fL, PDW: 10.5fL).
  • Statistical analysis revealed a significant difference (p < 0.05) in the mean values of these indices between the groups.
  • Larger platelets are associated with increased hemostatic activity.

Conclusions:

  • Elevated platelet count, MPV, and PDW are significant indicators in patients with acute coronary syndrome.
  • These findings suggest that increased platelet indices may serve as a risk factor for coronary thrombosis and events like myocardial infarction and unstable angina.
  • Identifying patients with larger platelets via routine hematological analysis could aid in preventive treatment strategies.

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