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Association between TP53 gene Arg72Pro polymorphism and Wilms' tumor risk in a Chinese population

Wen Fu1, Zhen-Jian Zhuo2, Wei Jia1

  • 1Department of Pediatric Urology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong; Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong.

Oncotargets and Therapy
|March 7, 2017
PubMed

Insights

The TP53 gene Arg72Pro polymorphism shows no overall association with Wilms' tumor risk in Chinese children. However, it may increase risk in younger children, suggesting an age-related effect.

Area of Science:

  • Genetics
  • Oncology
  • Pediatrics

Background:

  • Wilms' tumor is a common pediatric cancer.
  • TP53 gene mutations are linked to cancer development.
  • TP53 Arg72Pro polymorphism is a potential cancer risk factor.

Purpose of the Study:

  • To investigate the association between TP53 Arg72Pro polymorphism and Wilms' tumor risk in Chinese children.
  • To explore potential age-related effects of this polymorphism on Wilms' tumor susceptibility.

Main Methods:

  • Genotyping of the TP53 Arg72Pro polymorphism (rs1042522 C>G) using Taqman methodology.
  • Case-control study involving 145 Wilms' tumor patients and 531 cancer-free controls.
  • Stratified analysis based on age at diagnosis.

Main Results:

  • No significant overall association was found between TP53 Arg72Pro polymorphism and Wilms' tumor risk.
  • A statistically significant increased risk of Wilms' tumor was observed in children aged 18 months or younger carrying CG/GG genotypes (OR=2.04, P=0.049).

Conclusions:

  • The TP53 Arg72Pro polymorphism may not be a major risk factor for Wilms' tumor in general.
  • An age-dependent association suggests a potential role in early-onset Wilms' tumor.
  • Further validation in larger, diverse populations is warranted.

Keywords:
TP53Wilms’ tumorpolymorphismsusceptibility

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