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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs
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Effect of aging on stem cells.

Abu Shufian Ishtiaq Ahmed1, Matilda Hc Sheng1, Samiksha Wasnik1

  • 1Abu Shufian Ishtiaq Ahmed, Matilda HC Sheng, Samiksha Wasnik, David J Baylink, Kin-Hing William Lau, Regenerative Medicine Unit, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92354, United States.

World Journal of Experimental Medicine
|March 7, 2017
PubMed
Summary
This summary is machine-generated.

Aging impairs pluripotent stem cells (PSCs), affecting self-renewal and differentiation. Understanding this stem cell aging is key for treating age-related diseases and developing new therapies.

Keywords:
Adult stem cellsAgingBiological agingCellular agingMesenchymal stem cellPremature agingStem cell renewalTissue regeneration

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Area of Science:

  • Stem cell biology
  • Gerontology
  • Regenerative medicine

Background:

  • Pluripotent stem cells (PSCs) possess self-renewal and differentiation capabilities.
  • Aging negatively impacts stem cell function, including renewal and differentiation.
  • Deterioration of stem cell function with age is linked to age-associated disorders.

Purpose of the Study:

  • To review the basis of stem cell dysfunction in aging diseases.
  • To explore mechanisms causing age-related stem cell dysfunction.
  • To discuss emerging therapies for age-associated stem cell defects.

Main Methods:

  • Literature review of aging and stem cell research.
  • Analysis of studies on stem cell aging mechanisms.
  • Overview of current therapeutic strategies for stem cell defects.

Main Results:

  • Aging leads to impaired stem cell self-renewal and altered differentiation.
  • Stem cell dysfunction is implicated in the pathophysiology of aging-associated disorders.
  • Various mechanisms contribute to age-related stem cell dysfunction.

Conclusions:

  • Understanding stem cell aging is vital for comprehending aging diseases.
  • Targeting stem cell aging may offer novel therapeutic avenues for age-related conditions.
  • Further research into stem cell aging and therapies is warranted.