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Concurrent Pilomatrix Carcinoma and Diffuse Large B-Cell Lymphoma.

Luis Parra1, Marcos Martin2, María Garrido3

  • 1Hospital 12 de Octubre, Madrid, Spain.

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Summary

This case report details a rare pilomatrix carcinoma in a man with concurrent B-cell lymphoma. It underscores the importance of monitoring patients with persistent malignant skin tumors.

Keywords:
Long-standing skin lesionLymphomasPilomatrix carcinomaPilomatrixomaSkin tumors

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Pilomatrix carcinoma is a rare skin tumor originating from follicular matrix cells.
  • It can develop independently or transform from a benign pilomatrixoma.
  • Impaired immune surveillance, due to UV radiation or other cancers, may contribute to malignant transformation.

Purpose of the Study:

  • To report a rare case of pilomatrix carcinoma.
  • To highlight a concurrent diagnosis of high-grade B-cell lymphoma.
  • To emphasize the need for vigilant follow-up in patients with chronic malignant skin tumors.

Main Methods:

  • Case report of a 58-year-old male patient.
  • Documentation of a long-standing pilomatrix carcinoma on the right leg.
  • Identification of concurrent high-grade B-cell lymphoma in the same extremity.

Main Results:

  • A 58-year-old man presented with a decade-long history of pilomatrix carcinoma.
  • The patient had undergone repeated curettage for the lesion.
  • A high-grade B-cell lymphoma was diagnosed concurrently on the same leg.

Conclusions:

  • This case illustrates a rare association between pilomatrix carcinoma and B-cell lymphoma.
  • Close monitoring of patients with long-standing malignant skin tumors is crucial.
  • Understanding potential links between skin tumors and systemic conditions is vital for patient care.