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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model
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Cellular models to study schizophrenia: A systematic review.

Manasa Seshadri1, Debanjan Banerjee2, Biju Viswanath1

  • 1Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India; Centre for Brain Development and Repair, Institute of Stem Cell Biology and Regenerative Medicine, Bangalore, India.

Asian Journal of Psychiatry
|March 7, 2017
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cells (IPSCs) derived from schizophrenia patients offer insights into the disorder's biological underpinnings. These cellular models reveal key phenotypes like synaptic pathology and neural deficits, aiding schizophrenia research.

Keywords:
Cell modelNeuronPluripotentPsychosisSchizophrenia

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Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Psychiatry

Background:

  • Cellular reprogramming enables direct study of brain cells from neuropsychiatric disorder patients.
  • Induced pluripotent stem cells (IPSCs) and their neural derivatives are crucial for understanding schizophrenia's biological basis.

Purpose of the Study:

  • To systematically review the applications of IPSCs in schizophrenia research.
  • To consolidate findings on cellular phenotypes associated with schizophrenia.

Main Methods:

  • Systematic literature search of MEDLINE using terms related to pluripotency and schizophrenia/psychosis.
  • Inclusion of English-language studies utilizing IPSCs from schizophrenia patients.

Main Results:

  • Majority of studies derived neurons or neural stem cells from patient-derived IPSCs.
  • Identified key cellular phenotypes including synaptic pathology, neural migration/proliferation deficits, and abnormal oxidative phosphorylation.

Conclusions:

  • IPSC-based cellular modeling enhances biological understanding of schizophrenia.
  • Findings align with other research modalities (post-mortem studies, imaging, GWAS).
  • Future research should integrate refined study designs with clinical phenotyping for deeper insights.