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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Validation of antibiotic charges in administrative data for outpatient pediatric urologic procedures

K H Chan1, E A Moser2, M Cain3

  • 1Division of Pediatric Urology, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine, Indianapolis, IN, USA; Center for Pediatric and Adolescent Effectiveness Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

Journal of Pediatric Urology
|March 7, 2017
PubMed

Insights

This study found strong agreement between Pediatric Health Information System (PHIS) antibiotic charges and actual medication administration records. These findings support the validity of using administrative data for research.

Area of Science:

  • Health Informatics
  • Pediatric Surgery
  • Pharmacoeconomics

Background:

  • Administrative health data is increasingly used in research, raising questions about its accuracy.
  • Validating this data is crucial for reliable research outcomes.

Purpose of the Study:

  • To assess the concordance between Pediatric Health Information System (PHIS) antibiotic charges and medication administration records.
  • To evaluate the accuracy of PHIS data for perioperative antibiotic use in young males undergoing specific procedures.

Main Methods:

  • Retrospective chart review comparing PHIS perioperative antibiotic charges with electronic medication administration records.
  • Analysis focused on males under 10 years old who underwent outpatient penile/inguinal procedures between July 2013 and March 2015.

Main Results:

  • A high positive and negative agreement of 93.9% was observed between charges and administration.
  • Sensitivity was 96.8%, specificity was 87.2%, positive predictive value was 94.6%, and negative predictive value was 92.2%.

Conclusions:

  • There is strong agreement between PHIS pharmacy charges and medication administration data.
  • This supports the utility of PHIS data for research purposes concerning antibiotic use.
Abstract

Keywords:
Health Services ResearchValidation studies

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