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Updated: Mar 6, 2026
Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
Impact of variations in blood pressure with orthostatism on mortality: the HOMO study
Sonsoles M Velilla-Zancada1, Carlos Escobar-Cervantes, Luis Manzano-Espinosa
1aPrimary Care Center Arnedo, Arnedo, La Rioja bCardiology Department, La Paz University Hospital cInternal Medicine, Ramón y Cajal University Hospital, Madrid dPrimary Care Center Vallobín-La Florida, Oviedo, Asturias eDivision of Epidemiology and Disease Prevention, La Rioja Regional Authority,Logroño fPrimary Care Center Castilla-Hermida, Santander, Cantabria, Spain.
Objective:
The aim of this study was to determine the impact of orthostatic hypotension (OH) and orthostatic hypertension (OHT) on all-cause mortality.
Patients And Methods:
A total of, 1176 adults from the community over 18 years of age were included in this ambispective study. The mean follow-up was 9.4 years. OH and OHT were defined as a decrease or an increase, respectively, in systolic blood pressure (BP) of at least 20 mmHg and/or diastolic BP of at least 10 mmHg from sitting to standing position at 1 and/or 3 min after standing. The impact of systolic or diastolic OH and systolic or diastolic OHT at 1 and 3 min after standing was also analyzed separately.
Results:
In total, 135 individuals died during the follow-up. Neither OH [hazard ratio (HR) 1.23; 95% confidence interval (CI): 0.72-2.10] nor OHT (HR 0.90; 95% CI: 0.59-1.38) was associated with all-cause mortality in the adjusted models. In contrast, systolic OHT at 3 min (HR 2.31; 95% CI: 1.14-4.68) was independently associated with global mortality.
Conclusion:
Systolic OHT at 3 min is associated with all-cause mortality. The determination of this parameter could add valuable prognostic information during the routine examination of patients.
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