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Biologic response modifiers: Indications, implications, and insights

Benjamin P Davis1, Zuhair K Ballas2

  • 1Department of Internal Medicine, Division of Immunology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

The Journal of Allergy and Clinical Immunology
|March 7, 2017
PubMed

The field of biologic immune modulators is currently mushrooming at a dizzying pace. Although most of these biologics are tested and approved for one or a few indications, their unanticipated side effects and off-label use have contributed significantly to our understanding of basic immune mechanisms, the involvement of cytokines in several apparently nonimmunologic diseases, and the importance of compartmentalized immune responses. In this review we attempt to give a bird's-eye view of the major biologics and to highlight insights and implications derived from their secondary effects and adverse reactions.

Keywords:
Biologicsautoimmunitybiologic response modifiersimmune dysfunctionimmunodeficiencyinfection

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