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Biologic response modifiers: Indications, implications, and insights.

Benjamin P Davis1, Zuhair K Ballas2

  • 1Department of Internal Medicine, Division of Immunology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

The Journal of Allergy and Clinical Immunology
|March 7, 2017
PubMed
Summary
This summary is machine-generated.

Biologic immune modulators offer insights into immune mechanisms and cytokine roles in disease. Their side effects and off-label use significantly advance our understanding of complex immune responses.

Keywords:
Biologicsautoimmunitybiologic response modifiersimmune dysfunctionimmunodeficiencyinfection

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Area of Science:

  • Immunology
  • Pharmacology

Background:

  • The field of biologic immune modulators is rapidly expanding.
  • Biologics are typically approved for specific indications.

Purpose of the Study:

  • To review major biologic immune modulators.
  • To highlight insights gained from their secondary effects and adverse reactions.

Main Methods:

  • Literature review of biologic immune modulators.
  • Analysis of reported side effects and off-label use.

Main Results:

  • Unanticipated side effects and off-label use have enhanced understanding of immune mechanisms.
  • Cytokine involvement in nonimmunologic diseases is better understood.
  • The importance of compartmentalized immune responses is recognized.

Conclusions:

  • Biologic immune modulators provide valuable information beyond their primary indications.
  • Adverse reactions and off-label use are crucial for advancing immunological knowledge.