Related Experiment Video

Updated: Mar 6, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

16.6K

How We Manage Pediatric Deep Venous Thrombosis

Marisol Betensky1, Mark A Bittles2, Paul Colombani3

  • 1Pediatric Thrombosis Program, Johns Hopkins All Children's Hospital, St. Petersburg, Florida; Division of Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Seminars in Interventional Radiology
|March 8, 2017
PubMed

Insights

Pediatric venous thromboembolism (VTE) management is evolving due to increased incidence. This article outlines institutional approaches for pediatric VTE treatment, including anticoagulants and thrombolysis.

Area of Science:

  • Pediatric Hematology
  • Vascular Medicine
  • Critical Care Medicine

Background:

  • Increased incidence and recognition of pediatric venous thromboembolism (VTE) over the past two decades.
  • Current VTE management guidelines in children rely heavily on registry data, observational studies, or adult data extrapolation.
  • Lack of high-quality evidence leads to significant variability in pediatric VTE treatment approaches.

Purpose of the Study:

  • To present an institutional framework for managing VTE in children.
  • To consolidate available evidence, guidelines, and clinical considerations for pediatric VTE care.
  • To provide a comprehensive overview of therapeutic strategies for pediatric VTE.

Main Methods:

  • Review of institutional practices for pediatric VTE management.
  • Synthesis of existing evidence and clinical guidelines.
  • Analysis of various therapeutic options including anticoagulation, thrombolysis, and mechanical methods.

Main Results:

  • The article details institutional strategies for pediatric VTE management.
  • It covers a range of treatments: conventional anticoagulants, targeted parenteral anticoagulants, direct oral anticoagulants, thrombolysis, and mechanical interventions.
  • The approach is based on current evidence and clinical practice considerations.

Conclusions:

  • Standardized evidence-based approaches are needed for pediatric VTE management.
  • The outlined institutional strategy provides a framework for consistent and effective care.
  • Further research is crucial to enhance treatment guidelines for pediatric venous thromboembolism.

Keywords:
anticoagulantspediatricthrombolytic therapyvenous thromboembolism

More Related Videos

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

3.2K
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

18.0K

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
431
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
333
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
405
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
569
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
576
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
599