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Detrusor Underactivity Model in Rats by Conus Medullaris Transection
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Overactive bladder in children.

Sophie Ramsay1, Stéphane Bolduc2

  • 1Division of Urology, CHU de Québec-Université Laval, Quebec City, QC Canada.

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada
|March 8, 2017
PubMed
Summary
This summary is machine-generated.

Overactive bladder (OAB) in children significantly impacts quality of life. This review explores alternative treatments beyond standard antimuscarinics for pediatric OAB patients with suboptimal responses or side effects.

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Area of Science:

  • Pediatric Urology
  • Pharmacology
  • Clinical Medicine

Background:

  • Overactive bladder (OAB) is common in children, causing distress and affecting development.
  • Urgency and incontinence significantly impair pediatric patients' quality of life.
  • Current treatments, primarily antimuscarinics like oxybutynin, may have suboptimal efficacy or side effects.

Purpose of the Study:

  • To review alternative treatment options for pediatric overactive bladder.
  • To explore therapies beyond standard antimuscarinic agents.
  • To discuss conservative and invasive approaches for managing pediatric OAB.

Main Methods:

  • Literature review of pediatric overactive bladder treatments.
  • Analysis of alternative pharmacologic and non-pharmacologic interventions.
  • Evaluation of treatment efficacy and side effect profiles.

Main Results:

  • Oxybutynin is the only North American-approved agent for pediatric OAB.
  • Some patients do not respond well to antimuscarinics or experience significant side effects.
  • Alternative agents like tolterodine, fesoterodine, and others have been reported in pediatric use.

Conclusions:

  • There is a need for effective alternative treatments for pediatric overactive bladder.
  • A stepwise approach, from behavioral therapy to invasive procedures, is recommended.
  • Further research into alternative and approved therapies for pediatric OAB is warranted.