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Symmetry assisted tuning of bending and brittle multi-component forms of probenecid
U B Rao Khandavilli1, Balakrishna R Bhogala1, Anita R Maguire2
1Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Ireland. simon.lawrence@ucc.ie.
Abstract:
The mechanical flexibility known in the antihyperuricemia drug probenecid has been extended into multi-component systems using co-formers with two donor or acceptor sites, in contrast to systems with a single H-bond acceptor that exhibit brittle behaviour. The piperazinium salt demonstrates that GRAS co-formers can be used to maintain mechanical flexibility with drug molecules.
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