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Updated: Mar 6, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

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Arterial stiffness and cognitive function

Laure Joly1

  • 1Département de gériatrie, CHRU-Nancy, Nancy, France ; Inserm U1116, Faculté de médecine, Nancy, France ; Université de Lorraine, Nancy, France.

Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement
|March 8, 2017
PubMed

Insights

Arterial stiffness, a key indicator of cardiovascular risk, is linked to cognitive decline and dementia. Early detection and management of arterial stiffness are crucial for preventing serious health events.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Geriatrics

Background:

  • Arterial stiffness predicts cardiovascular morbidity and mortality, particularly in elderly, hypertensive patients.
  • Increased arterial stiffness during midlife is associated with cardiovascular events and cognitive decline.
  • Aortic stiffness correlates with poorer cognitive memory test performance.

Purpose of the Study:

  • To explore the association between arterial stiffness and cognitive decline.
  • To highlight the role of arterial stiffness in dementia pathogenesis.
  • To emphasize the importance of early detection and management of arterial stiffness.

Main Methods:

  • Pulse wave velocity assessment as the gold standard for measuring arterial stiffness.
  • Observational studies correlating aortic stiffness with cognitive function.
  • Analysis of microvascular alterations linked to arterial stiffness.

Main Results:

  • Arterial stiffness is associated with microvascular resistance, leukoaraiosis, and medial temporal lobe atrophy.
  • Higher aortic stiffness levels correlate with impaired cognitive memory performance.
  • Arterial stiffness contributes to the pathogenesis of dementia, including Alzheimer's disease.

Conclusions:

  • Arterial stiffness is a significant predictor of cardiovascular events and cognitive impairment.
  • Microvascular changes associated with arterial stiffness play a role in dementia.
  • Early detection and management of arterial stiffness are vital for mitigating cardiovascular and cognitive risks.

Keywords:
arterial stiffnesscognitive functiondementiamemory losspulsatile hemodynamics

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