An optimized microfabricated platform for the optical generation and detection of hyperpolarized ¹²⁹Xe

Low thermal-equilibrium nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) incompatible with small-scale microfluidic devices. Hyperpolarized ¹²⁹Xe gas has found use in the study of many materials but has required very large and expensive instrumentation. Recently a microfabricated device with modest instrumentation demonstrated all-optical hyperpolarization and detection of ¹²⁹Xe gas. This device was limited by ¹²⁹Xe polarizations less than 1%, ¹²⁹Xe NMR signals smaller than 20 nT, and transport of hyperpolarized ¹²⁹Xe over millimeter lengths. Higher polarizations, versatile detection schemes, and flow of ¹²⁹Xe over larger distances are desirable for wider applications. Here we demonstrate an ultra-sensitive microfabricated platform that achieves ¹²⁹Xe polarizations reaching 7%, NMR signals exceeding 1 μT, lifetimes up to 6 s, and simultaneous two-mode detection, consisting of a high-sensitivity in situ channel with signal-to-noise of 10⁵ and a lower-sensitivity ex situ detection channel which may be useful in a wider variety of conditions. ¹²⁹Xe is hyperpolarized and detected in locations more than 1 cm apart. Our versatile device is an optimal platform for microfluidic magnetic resonance in particular, but equally attractive for wider nuclear spin applications benefitting from ultra-sensitive detection, long coherences, and simple instrumentation.