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Updated: Mar 6, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Echocardiographic assessment in patients with chronic kidney disease: Current update
Samir Sulemane1, Vasileios F Panoulas1,2, Petros Nihoyannopoulos1
1Imperial College London, National Heart and Lung Institute, London, United Kingdom.
Insights
Patients with chronic kidney disease (CKD) face high cardiovascular risks. Echocardiography offers advanced tools to detect subclinical heart dysfunction and improve risk stratification in these patients.
Area of Science:
- Cardiology
- Nephrology
- Medical Imaging
Background:
- Chronic kidney disease (CKD) is strongly associated with increased cardiovascular mortality.
- Subclinical cardiac abnormalities, including left ventricular hypertrophy and systolic dysfunction, are common in CKD patients.
- Cardiac symptoms may be absent in many CKD patients, delaying diagnosis and treatment.
Purpose of the Study:
- To review current and emerging echocardiographic modalities for diagnosing heart disease in CKD patients.
- To explore how echocardiography can provide insights into the pathophysiology of cardiac dysfunction in CKD.
- To assess the utility of echocardiographic techniques for risk stratification of cardiac morbidity and mortality in renal disease.
Main Methods:
- Review of current and emerging echocardiographic techniques.
- Focus on speckle tracking echocardiography and 3D echocardiography.
- Discussion of diagnostic and prognostic applications in CKD.
Main Results:
- Echocardiography can detect subclinical cardiac changes in CKD patients.
- Emerging techniques like speckle tracking and 3D echocardiography offer detailed insights into cardiac function.
- These modalities aid in identifying patients at high risk for cardiovascular events.
Conclusions:
- Echocardiography is crucial for diagnosing and managing cardiac disease in CKD.
- Advanced echocardiographic techniques enhance the understanding and management of cardiovascular risk in renal disease.
- These tools are applicable to current clinical practice for improved patient outcomes.
Abstract:
Patients with chronic kidney disease (CKD) carry a high cardiovascular risk. An abundance of evidence has emerged in recent years establishing minor reductions in estimated glomerular filtration rate as an independent risk factor for cardiovascular mortality. Additionally, cardiac changes, such as left ventricular hypertrophy and impaired left ventricular systolic function, have been associated with an unfavorable prognosis. Despite the significant prevalence of underlying cardiac abnormalities, symptoms may not manifest in many patients with CKD. A range of available and emerging echocardiographic modalities may assist with diagnosing heart disease in CKD. Furthermore, some of these emerging techniques can give an important insight into the pathophysiology of subclinical dysfunction in CKD. This review discusses how current and emerging echocardiographic modalities such as speckle tracking echocardiography and 3D echocardiography might help cardiologists in providing important information to help with diagnosis and risk stratification of cardiac-related morbidity and mortality in patients with renal disease, as well applicability of these tools to current clinical practice.
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