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Updated: Mar 6, 2026

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

Endometrial microbiome.

Jason M Franasiak¹, Richard T Scott

¹aReproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey bThomas Jefferson University, Philadelphia, Pennsylvania, USA.

Current Opinion in Obstetrics & Gynecology

|March 8, 2017

Summary

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The human microbiome plays a crucial role in reproductive success. Further understanding of the reproductive tract microbiome and its dysbiosis can improve assisted reproduction outcomes.

Area of Science:

Reproductive Medicine
Microbiome Research
Genomics

Background:

Assisted reproduction has advanced, yet chromosomally normal blastocysts often fail to result in live births.
The human microbiome, encompassing microbes and their genomes, significantly impacts health and disease, with evolving insights into its role in reproduction.

Purpose of the Study:

To review the current understanding of the reproductive tract microbiome's impact on human reproduction.
To highlight advancements in characterizing the microbiome within the reproductive system.

Main Methods:

Utilizing new technologies for metagenomic sample analysis.
Characterizing the vaginal and endometrial microbiome in detail.

Main Results:

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Last Updated: Mar 6, 2026

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells

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New technologies enable comprehensive analysis of the reproductive tract microbiome.
Sites previously considered sterile are now known to harbor robust microbial communities.
Normal and abnormal vaginal and endometrial microbiomes have been better defined.

Conclusions:

The role of the microbiome in reproduction is still in early stages of understanding.
Characterizing and understanding reproductive tract dysbiosis is key to potential therapeutic interventions.
Expert manipulation of the reproductive tract microbiome may improve reproductive outcomes.