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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

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Diastolic dysfunction in hypertension

R Nazário Leão1, P Marques da Silva2

  • 1Unidade Funcional Medicina 2, Hospital São José, Centro Hospitalar Lisboa Central - EPE, Lisboa, Portugal; Nova Medical School, Lisboa, Portugal.

Hipertension Y Riesgo Vascular
|March 8, 2017
PubMed

Insights

Hypertension can lead to asymptomatic left ventricular diastolic dysfunction, a precursor to heart failure. Early diagnosis and treatment are crucial for managing this condition in hypertensive patients.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Heart Failure Studies

Background:

  • Hypertension and coronary heart disease are leading risk factors for heart failure.
  • Hypertensive heart disease progresses through myocardial fibrosis and altered left ventricular geometry, often asymptomatically.
  • Left ventricular diastolic dysfunction (LVDD) is a key, underappreciated component of this continuum.

Purpose of the Study:

  • To review the epidemiology of LVDD in hypertensive patients.
  • To discuss the latest advancements in understanding LVDD pathophysiology.
  • To cover current diagnostic and therapeutic strategies for LVDD.

Main Methods:

  • Literature review of epidemiological data.
  • Synthesis of recent research on LVDD pathophysiology.
  • Analysis of diagnostic tools and treatment options for LVDD.

Main Results:

  • LVDD is highly prevalent in hypertensive individuals.
  • LVDD precedes overt heart failure symptoms and is linked to higher cardiovascular risk.
  • Understanding LVDD is critical for clinical practice, though it remains poorly understood.

Conclusions:

  • LVDD is a significant clinical entity in hypertensive patients, associated with adverse outcomes.
  • Further research into pathophysiology, diagnosis, and treatment is warranted.
  • This review provides a comprehensive overview for clinicians and researchers.

Keywords:
Diastolic dysfunctionDisfunción diastólicaEnfermedad cardíaca hipertensivaGeometría ventricular izquierdaHeart failure with preserved ejection fractionHipertensiónHypertensionHypertensive heart diseaseInsuficiencia cardíaca con fracción de eyección preservadaLeft Ventricular geometry

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