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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Imaging Studies III: Computed Tomography01:27

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Related Experiment Video

Updated: Mar 6, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
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Optical coherence tomography based angiography [Invited].

Chieh-Li Chen1, Ruikang K Wang1

  • 1Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, USA; Department of Ophthalmology, University of Washington, 325 9th Ave, Seattle, WA 98104, USA.

Biomedical Optics Express
|March 9, 2017
PubMed
Summary

Optical coherence tomography angiography (OCTA) non-invasively visualizes 3D vascular networks using red blood cells. This technology has rapidly advanced clinical ophthalmology and shows promise for various pre-clinical and clinical applications.

Keywords:
(110.4500) Optical coherence tomography(170.2655) Functional monitoring and imaging(170.3880) Medical and biological imaging

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Area of Science:

  • Biomedical Imaging
  • Ophthalmology
  • Medical Technology

Background:

  • Optical coherence tomography angiography (OCTA) offers non-invasive, 3D vascular imaging.
  • It utilizes endogenous contrast from flowing red blood cells, eliminating the need for dye injections.
  • OCTA has seen rapid clinical translation, particularly in ophthalmology.

Purpose of the Study:

  • To provide a technical overview of OCTA developments.
  • To explore potential pre-clinical and clinical applications of OCTA.
  • To discuss future perspectives of OCTA technology, with an emphasis on ophthalmic applications.

Main Methods:

  • Development of various OCTA algorithms utilizing different OCT signal components (phase, intensity, complex).
  • In vivo detection of functional micro-vasculatures.
  • Application of OCTA in retinal and skin pathologies, tumors, and hypoxia studies.

Main Results:

  • Demonstrated clinical value in revealing micro-vasculatures in biological tissues.
  • Successful identification of abnormal vascular networks and vessel impairment zones.
  • Effective detection of angiogenesis and monitoring of hypoxia responses.

Conclusions:

  • OCTA is a powerful tool for visualizing functional vasculature non-invasively.
  • Its applications extend across ophthalmology, dermatology, and neurology.
  • Continued development promises expanded pre-clinical and clinical utility.