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5-substituted 2'-fluoro-arabinonucleosides as potential antiviral agents
J T Huang1, R F Schinazi, H Gadler
1Sloan-Kettering Institute for Cancer Research, Graduate School of Medical Sciences, Cornell University, New York, NY 10021.
Nucleic Acids Symposium Series
|January 1, 1987
Abstract:
In order to study the electronic effects of 5-substituents of 2'-fluoro-ara-U on antiviral activity, eight nucleosides were synthesized and screened for their activity. Preliminary in vitro studies revealed that 5-thiocyano-, 5-hydroxy- and 5-formyl-ara-U are moderately active against HSV-1, HSV-2 and VZV, but they are also cytotoxic. None of these showed significant activity against CMV.