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Limbic postictal events: anatomical substrates and opioid receptor involvement
1Department of Neurology, Reed Neurological Institute, Los Angeles, California.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|January 1, 1987
Summary
Kindled seizures in rats mimic human complex partial seizures, causing motor deficits and affective disruption. Opioid receptors and brain regions like the substantia nigra and hippocampus are implicated in these postictal effects.
Area of Science:
- Neuroscience
- Epilepsy Research
- Pharmacology
Background:
- Amygdaloid kindled seizures in rats share similarities with human complex partial seizures.
- Postictal effects observed include motor deficits, altered affective responses, explosiveness, and seizure suppression.
Purpose of the Study:
- To investigate the neurobiological mechanisms underlying postictal effects following kindled seizures in rats.
- To propose potential therapeutic targets for managing postictal events in humans.
Main Methods:
- Utilized 2-deoxyglucose (2DG) studies in kindled rats.
- Reviewed existing literature on opioid receptor involvement and brain region mediation.
Main Results:
- Postictal motor deficits may involve the substantia nigra, while affective disruption and seizure suppression may be mediated by the hippocampus.
- Opioid receptors (mu, kappa, delta) are implicated in mediating various postictal effects, with specific receptors linked to motor deficits, affective changes, and seizure suppression.
Conclusions:
- The study provides insights into the mechanisms of postictal effects following kindled seizures, suggesting parallels with human complex partial seizures.
- Findings suggest potential therapeutic strategies targeting specific opioid receptors and brain regions for managing postictal sequelae.