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Dietary Fat Inflames CD4+ T Cell Memory in Obesity
Nicole M Chapman1, Hongbo Chi1
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cell Metabolism
|March 9, 2017
Abstract:
T cells promote inflammation in obesity, but how metabolic stress associated with obesity alters T cell responses remains unclear. In this issue of Cell Metabolism,Mauro et al. (2017) demonstrate that saturated fatty acids directly increase effector-memory T cell formation by amplifying T cell antigen-receptor-induced PI3K/Akt signaling.
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