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Published on: January 29, 2016
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Physical activity is associated with a decreased multiple sclerosis risk: The EnvIMS study.
Kristin Wesnes1, Kjell-Morten Myhr2, Trond Riise3
1Department of Clinical Medicine, University of Bergen, Bergen, Norway/The Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|March 10, 2017
Summary
Vigorous physical activity (PA) may reduce the risk of developing multiple sclerosis (MS). This study found that higher levels of vigorous PA were associated with lower MS risk, independent of other known factors.
Area of Science:
- Neurology
- Epidemiology
- Lifestyle Medicine
Background:
- Lifestyle factors like smoking and obesity are linked to multiple sclerosis (MS) risk.
- The role of physical activity (PA) in MS development is under investigation.
Purpose of the Study:
- To investigate the association between physical activity and MS risk across Italy, Norway, and Sweden.
- To assess if established risk factors influence the relationship between PA and MS.
Main Methods:
- A case-control study involving 1904 MS cases and 3694 controls.
- Participants reported adolescent weekly physical activity levels (light and vigorous).
- Logistic regression analysis was used to estimate odds ratios (ORs) and confidence intervals (CIs), adjusting for confounders.
Main Results:
- Vigorous physical activity showed an inverse association with MS risk (p-trend < 0.001).
- Higher levels of vigorous PA were linked to a reduced risk (OR 0.74; 95% CI: 0.63-0.87).
- This association remained consistent across countries and after adjusting for factors like smoking and body size; light PA showed no association.
Conclusions:
- Vigorous physical activity appears to be a significant factor in modifying the risk of developing MS.
- The protective effect of vigorous PA is independent of other known risk factors for MS.
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