Two new C₁₉-diterpenoid alkaloids from Aconitum tsaii

Area of Science:

• Natural Product Chemistry
• Organic Chemistry
• Pharmacognosy

Background:

• Aconitum species are known sources of bioactive alkaloids.
• Diterpenoid alkaloids represent a significant class of natural products with diverse pharmacological activities.
• Aconitum tsaii is a lesser-studied species within the Aconitum genus.

Purpose of the Study:

• To isolate and characterize new chemical constituents from the roots of Aconitum tsaii.
• To elucidate the structures of novel C19-diterpenoid alkaloids.

Main Methods:

• Isolation of compounds using chromatographic techniques.
• Structure elucidation employing Infrared (IR), Ultraviolet (UV), Nuclear Magnetic Resonance (NMR) spectroscopy (1D and 2D), and Mass Spectrometry (MS).

Main Results:

• Two new C19-diterpenoid alkaloids, named 14-benzoylliljestrandisine (1) and 14-anisoylliljestrandisine (2), were successfully isolated.
• The structures of compounds 1 and 2 were definitively determined through comprehensive spectroscopic analysis.

Conclusions:

• The study expands the known chemical diversity of Aconitum alkaloids.
• The identification of these novel compounds contributes to the chemotaxonomic understanding of Aconitum tsaii.