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Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Oral Drug Delivery Systems: Continuous-Release Systems01:26

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Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
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Oral Drug Delivery Systems: Delayed-Release Systems01:11

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Drug Delivery Systems: Different Types01:27

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Pulmonary delivery systems for polyphenols.

Valentina Trotta1, Santo Scalia1

  • 1a Department of Chemical and Pharmaceutical Sciences , University of Ferrara , Ferrara , Italy.

Drug Development and Industrial Pharmacy
|March 10, 2017
PubMed
Summary
This summary is machine-generated.

Polyphenols show promise for treating lung inflammation. This review covers their antioxidant and anti-inflammatory benefits and explores inhalable formulations for effective delivery to the respiratory tract.

Keywords:
Polyphenolsinflammationinhalable formulationslung deliveryoxidative stresspulmonary diseases

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Area of Science:

  • Pharmacology
  • Drug Delivery
  • Respiratory Medicine

Background:

  • Naturally occurring polyphenols possess beneficial pharmacological properties.
  • Inflammatory pulmonary diseases represent a significant therapeutic challenge.
  • Efficient delivery of therapeutic agents to the respiratory tract is crucial for treating lung pathologies.

Purpose of the Study:

  • To review the pharmacological properties of polyphenols for treating inflammatory lung diseases.
  • To overview inhalable formulations for effective polyphenol delivery to the respiratory tract.
  • To emphasize the technological aspects influencing pulmonary drug delivery.

Main Methods:

  • Literature review of studies on polyphenol biological activities.
  • Examination of various polyphenol-based inhalable formulations.
  • Analysis of preparation methodologies, aerosol performance, and lung deposition.
  • Assessment of in vitro and in vivo polyphenol uptake by pulmonary epithelial cells.

Main Results:

  • Polyphenols exhibit significant antioxidant and anti-inflammatory activities.
  • Therapeutic effects of polyphenols on lung pathologies are documented.
  • Various inhalable formulations are being developed for efficient pulmonary delivery.
  • Technological factors critically influence drug deposition and uptake in the lungs.

Conclusions:

  • Polyphenols are promising candidates for treating inflammatory pulmonary diseases.
  • Inhalable formulations offer an effective strategy for delivering polyphenols to the lungs.
  • Further research into formulation technology is essential for optimizing polyphenol pulmonary delivery.