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Updated: Mar 6, 2026

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal
Published on: May 30, 2012
Regulation of Embryonic Stem Cell Self-Renewal and Differentiation by MicroRNAs
Xi Ran1,2, Chun-Hong Xiao3, Gui-Ming Xiang1
11 Department of Medical Laboratory, Xinqiao Hospital, Third Military Medical University , Chongqing, China .
Abstract:
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. They play an important role in various cellular processes such as apoptosis, differentiation, secretion, and proliferation. Embryonic stem cells (ESCs) are derived from the inner cell mass of the blastocyst stage of the embryo. miRNAs are critical factors for the self-renewal and differentiation of ESCs. In this review, we will focus on the role of miRNAs in the self-renewal and directional differentiation of ESCs. We will present the current knowledge on key points related to miRNA biogenesis and their function in ESCs.
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