Cyclic AMP derivatives injected into the inferior colliculus induce audiogenic seizure-like phenomena in normal rats

Microinjection of 10 micrograms of either dibutyryl cyclic AMP or 8-bromo-cyclic AMP into the inferior colliculus of normal rats induced audiogenic seizure-like phenomena, which were intensified by sound stimulation. Microinjection of either cyclic AMP derivatives into areas surrounding the inferior colliculus or in the substantia nigra-region did not induce any such effects. These data suggest that there may be a close relationship between audiogenic seizures and cyclic AMP metabolism of the inferior colliculus.