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Cardiac Dysfunction and Heart Failure in Hematopoietic Cell Transplantation Survivors: Emerging Paradigms in

Saro H Armenian1, Thomas D Ryan2, Michel G Khouri3

  • 1Division of Outcomes Research, Department of Population Sciences, Comprehensive Cancer Center, City of Hope, 1500 East Duarte Road, Duarte, CA 91010-3000, USA.

Heart Failure Clinics
|March 11, 2017
PubMed

Insights

Hematopoietic cell transplantation (HCT) survivors face increased risks of cardiovascular disease (CVD). Early detection and prevention strategies are crucial for managing CVD in this growing population.

Area of Science:

  • Oncology
  • Cardiology
  • Transplantation Medicine

Background:

  • Hematopoietic cell transplantation (HCT) offers curative potential for various malignancies.
  • An increasing number of HCT survivors are living longer.
  • These survivors are susceptible to serious cardiovascular disease (CVD) complications.

Purpose of the Study:

  • To provide an overview of cardiovascular disease (CVD) in hematopoietic cell transplantation (HCT) survivors.
  • To detail the pathophysiology of CVD in HCT survivors, focusing on unique therapeutic exposures and comorbidities.
  • To discuss novel screening and prevention strategies for CVD in HCT survivors.

Main Methods:

  • Literature review and synthesis of existing research on CVD in HCT survivors.
  • Emphasis on pathophysiology, therapeutic exposures, and comorbidities specific to HCT.
  • Exploration of screening and prevention strategies from related cancer populations.

Main Results:

  • HCT survivors are at significant risk for developing cardiovascular disease (CVD).
  • Therapeutic exposures (e.g., radiation, chemotherapy) and unique comorbidities contribute to CVD risk.
  • Novel screening and prevention strategies show promise for this population.

Conclusions:

  • Cardiovascular disease (CVD) is a critical concern for hematopoietic cell transplantation (HCT) survivors.
  • Understanding HCT-specific risk factors is essential for effective CVD management.
  • Collaboration between cardiologists and hematologists can improve cardiovascular health outcomes for HCT survivors.

Keywords:
Cardiac dysfunctionHeart failureHematopoietic cell transplantationPathophysiologyPreventionScreeningSurvivors

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