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Updated: Sep 11, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
Published on: March 17, 2022
Heart Failure and Embolism
Charlotte L Frost1, Alexandra Zăvoi2, Stijn Lochy2
1Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Abstract:
Heart failure and embolism frequently coexist and share common pathophysiologic mechanisms, including stasis, endothelial dysfunction and inflammation. Their clinical presentations can often be misleading, which makes the diagnostic challenging and mandates appropriate use of different imaging techniques. This article summarizes the pathophysiological links, diagnostic challenges and management strategies of these 2 entities. It also outlines evidence-based and guideline-directed strategies for prevention and treatment, including the role of inflammation, atrial cardiomyopathy and updated anticoagulation recommendations.
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