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Ultrasound and Histologic Examination after Subcutaneous Injection of Two Volumizing Hyaluronic Acid Fillers: A
Patrick Micheels1, Stéphanie Besse1, Didier Sarazin1
1Private Practice, Geneva, Switzerland; MedImage RX Institute, Geneva, Switzerland; Laboratoire Viollier, Geneva, Switzerland; Private Practice, Neuchâtel, Switzerland; and Private Practice, Oudenaarde, Belgium.
Plastic and Reconstructive Surgery. Global Open
|March 11, 2017
Summary
Cohesive Polydensified Matrix (CPM) hyaluronic acid (HA) fillers maintain better tissue integrity and show less inflammation than Vycross HA fillers after subcutaneous injection, according to ultrasound and histologic analysis.
Area of Science:
- Dermatology
- Biomaterials Science
- Medical Imaging
Background:
- Hyaluronic acid (HA) fillers are widely used for subcutaneous injection.
- Crosslinking technology influences the behavior of HA fillers.
- Understanding filler behavior is crucial for effective aesthetic and reconstructive procedures.
Purpose of the Study:
- To investigate the influence of crosslinking technology on the ultrasound and histologic characteristics of two different HA fillers.
- To compare the tissue integration and inflammatory response of Cohesive Polydensified Matrix (CPM) and Vycross HA fillers.
Main Methods:
- Subcutaneous injection of CPM and Vycross HA fillers into human tissue.
- Ultrasound imaging at 0 and 8 days post-injection.
- Histologic analysis at 0 and 21 days post-injection.
- Rheologic testing to assess mechanical properties.
Main Results:
- Ultrasound revealed differences in echogenicity and persistence between CPM and Vycross, particularly after massage and with different injection techniques.
- Histology confirmed ultrasound findings, showing CPM with less inflammatory reaction compared to Vycross, which exhibited a more pronounced inflammatory response with macrophages and giant cells.
- Rheologic tests indicated CPM possesses greater cohesivity and resistance to traction than Vycross.
Conclusions:
- CPM HA volumizer demonstrates superior tissue integrity post-subcutaneous injection compared to Vycross.
- CPM exhibits a reduced inflammatory profile relative to Vycross.
- Crosslinking technology significantly impacts the in-situ behavior and tissue interaction of HA fillers.
