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Clinical Outcomes in Breast Reconstruction Patients Using a Sterile Acellular Dermal Matrix Allograft
1Womack Army Medical Center, Fort Bragg, NC, 28310, USA. juan.a.ortizperez.mil@mail.mil.
Aesthetic Plastic Surgery
|March 11, 2017
Summary
Human acellular dermal matrices (ADMs) facilitate breast reconstruction. DermACELL (D-ADM) demonstrated low complication rates and high success in tissue expander breast reconstruction, supporting its use.
Area of Science:
- Plastic Surgery
- Regenerative Medicine
- Biomaterials
Background:
- Human acellular dermal matrices (ADMs) are utilized in breast reconstruction.
- Concerns exist regarding increased complication rates, particularly infection, with ADM use.
- DermACELL (D-ADM) offers potential benefits due to its decellularization and sterilization properties.
Purpose of the Study:
- To evaluate the safety and effectiveness of DermACELL (D-ADM) in augmented breast reconstruction.
- To assess complication rates associated with D-ADM use in tissue expander breast reconstruction.
Main Methods:
- Retrospective chart review of patients undergoing breast reconstruction with D-ADM.
- Study population included 38 subjects and 58 breasts at a military hospital.
- Level of Evidence: IV.
Main Results:
- Successful outcomes were observed in 96.6% of breasts (56/58) with a median healing time of 27 weeks.
- Complication rates were low: 1.7% for surgical site infection and 1.7% for red breast syndrome.
- 24.1% and 25.9% of reconstructions received post-reconstruction radiation and chemotherapy, respectively.
Conclusions:
- DermACELL (D-ADM) demonstrates low complication rates in breast reconstruction.
- High success and patient satisfaction rates support the use of D-ADM.
- D-ADM is a viable option for tissue expander breast reconstruction.