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Updated: Mar 6, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida
Jian-Yong Zhu1, Chun-Yang Zhang1, Jing-Jing Dai2
1a Central Laboratory , Seventh People's Hospital of Shanghai University of TCM , Shanghai , P. R. China.
Abstract:
Chemical investigation of the Jatropha multifida has led to the isolation of nine diterpenoids (1-9), including a new jatromulone A, four podocarpane diterpenoids (2-5), two lathyrane-type diterpenoids (6 and 7) and two dinorditerpenoids (8 and 9). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1 were determined by CD analysis. All of the diterpenoids were screened for inhibitory activity against thioredoxin reductase (TrxR), which is a potential target for cancer chemotherapy with redox balance and antioxidant functions. Compounds 6 and 7 exhibited stronger activity (IC50: 23.4 and 10.6 μM, respectively) than the positive control, curcumin (IC50 = 25.0 μM). Compounds 2-9 were isolated from J. multifida for the first time.
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