Multimodal Imaging Including Optical Coherence Tomography Angiography in Serpiginous Choroiditis

Area of Science:

• Ophthalmology
• Medical Imaging
• Retinal Diseases

Background:

• Serpiginous choroiditis is an inflammatory condition affecting the choroid and retina.
• Early diagnosis and understanding of its pathology are crucial for managing visual outcomes.

Observation:

• A case study details multimodal imaging findings in a patient with active serpiginous choroiditis.
• Imaging modalities included fluorescein angiography, swept-source optical coherence tomography (SS-OCT), OCT angiography, fundus autofluorescence (FAF), and retromode imaging.

Findings:

• Multimodal imaging highlighted subretinal lesions with characteristic FAF and retromode imaging features.
• SS-OCT showed choriocapillaris changes, including thickened hyporeflective spaces and hyperreflective spots.
• OCT angiography revealed reduced choriocapillaris vascularity, persisting photoreceptor defects despite treatment.

Implications:

• Choriocapillaris inflammation is identified as a key pathological feature of serpiginous choroiditis.
• Damage to the choriocapillaris can lead to photoreceptor disruption and permanent vision loss.
• Multimodal imaging provides valuable insights into the disease process and its impact on visual function.