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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Tissue Renewal without Stem Cells01:23

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Related Experiment Video

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Personalized Regenerative Medicine.

Babak Arjmand1, Parisa Goodarzi2, Fereshteh Mohamadi-Jahani2

  • 1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Acta Medica Iranica
|March 12, 2017
PubMed
Summary

Personalized medicine, including cellular therapy, tailors treatments using patient-specific data. Induced pluripotent stem cells (iPSCs) offer promising avenues for individualized regenerative medicine approaches.

Keywords:
Induced pluripotent stem cellsPersonalized medicinePrecision medicineRegenerative medicineStem cell therapy

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Area of Science:

  • Regenerative Medicine
  • Pharmacogenetics
  • Cellular Therapy

Background:

  • Personalized medicine, also known as precision medicine, tailors treatments to individual patients based on genetic and pharmacogenomic data.
  • While initially rooted in pharmacogenetics, personalized medicine now encompasses broader healthcare fields, including regenerative medicine and cellular therapy.
  • Cellular therapies utilize cell-based products to develop individualized treatment strategies.

Purpose of the Study:

  • To explore the role of personalized medicine, particularly cellular therapy, in tailoring medical treatments.
  • To highlight the potential of induced pluripotent stem cells (iPSCs) as a source for personalized cell therapies.
  • To discuss critical factors influencing the efficacy of individualized cellular therapies.

Main Methods:

  • Review of current literature on personalized medicine, pharmacogenetics, and regenerative medicine.
  • Analysis of different stem cell sources, including mesenchymal stem cells, embryonic stem cells, and iPSCs.
  • Identification of key factors influencing the success of personalized cellular therapies.

Main Results:

  • Induced pluripotent stem cells (iPSCs) are identified as suitable candidates for personalized cell therapies due to their individual pluripotent nature.
  • Cellular therapies inherently offer a personalized approach, but require adjustment based on patient-specific profiles for optimal outcomes.
  • Successful personalized stem cell therapy depends on considering recipient and donor factors, the cellular environment, and stem cell source criteria.

Conclusions:

  • Personalized and precision medicine represent a shift towards individualized healthcare, with cellular therapy playing a significant role.
  • Induced pluripotent stem cells (iPSCs) hold substantial promise for developing effective personalized cellular treatments.
  • Optimizing personalized cellular therapy necessitates a comprehensive approach, considering patient-specific factors and stem cell characteristics for maximum therapeutic benefit.