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Downbeat nystagmus due to ranitidine in a pediatric patient
Laura Butragueño Laiseca1, Blanca Toledo Del Castillo1, Cristina Rodríguez Jimenez1
1Department of Pediatrics, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Background:
Ranitidine has not been considered as a potential cause of ocular movement conditions. However, it is known that the vestibular nucleus complex, that has a key role in gaze control and vestibule-ocular reflexes, receives hypothalamic histaminergic innervations. Some studies reported the effect of ranitidine blocking the excitatory responses of vestibular nuclei neurons to histamine.
Case Report:
We report the first case of a downbeat nystagmus secondary to ranitidine in an infant. A 3-month-old female developed a downbeat gaze after starting treatment with ranitidine for a pediatric gastroesophageal reflux disease. Microbiological test were negative and neuroblastoma evaluation was normal.
Conclusion:
As ranitidine is widely prescribed in the pediatric population, clinicians should be aware of its potential to cause ocular movements disorders.
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