Oxytocin reduces amygdala responses during threat approach

Oxytocin reduces amygdala responses to threatening social stimuli in males and has been suggested to facilitate approach-related processing by either decreasing anxiety or intensifying salience. The current administration study tested whether oxytocin either reduces or enhances amygdala responses during threat approach in a placebo-controlled randomized, double-blind, between-subjects design with 52 healthy males undergoing fMRI during a social approach-avoidance task. Oxytocin decreased amygdala activation during threat approach and not during threat avoidance. This neural effect supports oxytocin's social anxiolytic effects and provides a neuroendocrine mechanism promoting social approach. The findings may yield clinical implications for individuals suffering from dysregulations of social approach such as patients with anxiety disorders.