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Relation of Thyroid Hormone Levels with Fluid-Resistant Shock among Preterm Septicemic Neonates
Sourabh Dutta1, Sarvendra Singh, Anish Bhattacharya
1Departments of Pediatrics and *Nuclear Medicine, PGIMER, Chandigarh, India. Correspondence to: Prof. Sourabh Dutta, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India. sourabhdutta@yahoo.co.in.
Objective:
To compare thyroid hormone levels between septicemic preterm neonates with and without shock.
Methods:
Preterm septicemic infants with shock constituted Group A (n=36) and those without shock constituted Group B, with groups matched (1:1) for gestation and postnatal age. Those with maternal thyroid disorders, thyrotropic medication and life expectancy <12 hours were excluded. We compared serum tri-iodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) between the groups by univariate and multivariate (adjusting for SNAPPE-II) analysis.
Results:
Median (IQR) TSH was significantly lower in Group A [1.39 (0.83,3.48)] vs Group B [5.1 (2.32,7.19)] mmol/dL (P<0.001). Serum T3 and T4 were also lower in Group A (P<0.001). On multivariate analysis, none of these measures were independently associated with septic shock.
Conclusion:
Thyroid hormone levels do not independently predict presence of shock among septic preterms.
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