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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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The intestinal microenvironment in sepsis.

Katherine T Fay1, Mandy L Ford2, Craig M Coopersmith3

  • 1Department of Surgery, Emory University School of Medicine, Atlanta, GA, United States.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|March 14, 2017
PubMed
Summary
This summary is machine-generated.

The gut

Keywords:
EpitheliumGutImmune systemIntestineMicrobiomeSepsis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • The gastrointestinal tract is implicated as a driver of multiple organ dysfunction syndrome.
  • The gut's microenvironment comprises epithelium, immune cells, and the microbiome, crucial for homeostasis.
  • This microenvironment is disrupted during sepsis, causing local and systemic injury.

Purpose of the Study:

  • To review the interplay between the gut epithelium, lymphocytes, and bacteria in health and sepsis.
  • To explore therapeutic strategies targeting the intestinal microenvironment in sepsis.

Main Methods:

  • Literature review focusing on the gastrointestinal tract's role in sepsis.
  • Analysis of the interactions between epithelial cells, lymphocytes, and the gut microbiome.
  • Examination of pathological changes in the gut during sepsis.

Main Results:

  • The gastrointestinal microenvironment undergoes significant perturbation during sepsis.
  • Pathological changes in the gut contribute to both local and distant organ injury.
  • The epithelium, immune system, and microbiome are key players in sepsis-induced gut dysfunction.

Conclusions:

  • The gastrointestinal tract's microenvironment is a critical factor in sepsis pathogenesis.
  • Targeting the intestinal microenvironment offers potential therapeutic avenues for septic patients.