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Updated: Mar 6, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor

Kari E Hernandez1, Hans Renata1, Russell D Lewis2

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, United States.

ACS Catalysis
|March 14, 2017
PubMed

Keywords:
Bacillus subtilisbiocatalysiscyclopropanationdirected evolutionticagrelortruncated globin

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