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Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
Published on: September 3, 2020
New Delivery Systems of Stem Cells for Vascular Regeneration in Ischemia
Adegbenro Omotuyi John Fakoya1
1Department of Anatomical Sciences, All Saints University School of Medicine , Roseau , Dominica.
Insights
Cardiovascular disease complications are costly. New stem cell delivery methods aim to improve vascular regeneration and tissue repair, enhancing patient quality of life.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
- Biotechnology
Background:
- Cardiovascular diseases (CVDs) impose significant financial burdens due to chronic complications like heart failure and limb ischemia.
- Current pharmacological and surgical treatments often fail to restore quality of life, necessitating novel therapeutic approaches.
- Stem cell therapy shows promise for vascular regeneration and tissue remodeling in CVDs.
Purpose of the Study:
- To review advanced stem cell delivery strategies for improving vascular regeneration in cardiovascular disease.
- To explore methods enhancing stem cell retention, survival, and engraftment for long-term therapeutic benefits.
- To evaluate the potential of combining stem cell therapy with macrophage-based approaches.
Main Methods:
- Review of literature on various stem cell delivery techniques, including scaffolds, enhanced delivery systems (magnet, ultrasound), and homing strategies.
- Analysis of stem cell modulation, preconditioning, and pretreatment methods.
- Appraisal of combination therapies, specifically stem cells with macrophages.
Main Results:
- Inadequate stem cell retention, survival, and engraftment limit the efficacy of current stem cell therapies for CVDs.
- Numerous innovative delivery methods are being investigated to overcome these limitations and improve regenerative outcomes.
- Macrophages play a crucial role in repair, remodeling, and angiogenesis, suggesting potential synergistic effects with stem cells.
Conclusions:
- Optimizing stem cell delivery is critical for realizing their full therapeutic potential in treating cardiovascular disease complications.
- Advanced techniques and combination therapies, such as with macrophages, offer promising avenues for enhanced vascular regeneration and tissue repair.
- Further research into these enhanced delivery and combination strategies is essential for improving patient quality of life affected by CVDs.
Abstract:
The finances of patients and countries are increasingly overwhelmed with the plague of cardiovascular diseases as a result of having to chronically manage the associated complications of ischemia such as heart failures, neurological deficits, chronic limb ulcers, gangrenes, and amputations. Hence, scientific research has sought for alternate therapies since pharmacological and surgical treatments have fallen below expectations in providing the desired quality of life. The advent of stem cells research has raised expectations with respect to vascular regeneration and tissue remodeling, hence assuring the patients of the possibility of an improved quality of life. However, these supposed encouraging results have been short-lived as the retention, survival, and engraftment rates of these cells appear to be inadequate; hence, the long-term beneficial effects of these cells cannot be ascertained. These drawbacks have led to the relentless research into better ways to deliver stem cells or angiogenic factors (which mobilize stem cells) to the regions of interest to facilitate increased retention, survival, engraftment, and regeneration. This review considered methods, such as the use of scaffolds, retrograde coronary delivery, improved combinations, stem cell pretreatment, preconditioning, stem cell exosomes, mannitol, magnet, and ultrasound-enhanced delivery, homing techniques, and stem cell modulation. Furthermore, the study appraised the possibility of a combination therapy of stem cells and macrophages, considering the enormous role macrophages play in repair, remodeling, and angiogenesis.
