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Updated: Jan 26, 2026
Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
Published on: June 14, 2024
The role of Siglec-1 in HIV-1/macrophage interaction
Ousman Jobe1, Jiae Kim1, Mangala Rao2
1Henry M. Jackson Foundation for the Advancement of Military Medicine, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910, USA; Laboratory of Adjuvant and Antigen Research, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910, USA.
Abstract:
Although CD4 T-cells are a major target for HIV, recent work has demonstrated the ability of macrophages despite expressing relatively low levels of CD4, to be a target of the virus. Our recent study has found that the presence of growth factors not only play a role in the phenotype of these monocyte-derived-macrophages, but also are an important aspect of the permissiveness of these cells to infection. The work utilized cellular and biophysical methods to examine Siglec-1 on macrophages as a primary receptor in HIV-1 infection. These findings support the notion that Siglec-1 and macrophages and their interactions with the HIV-1 envelope should be considered in HIV-1 vaccine development.
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