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Updated: Mar 5, 2026

Toeprinting Analysis of Translation Initiation Complex Formation on Mammalian mRNAs
Published on: May 10, 2018
Translational control of mRNAs by 3'-Untranslated region binding proteins
Akio Yamashita1, Osamu Takeuchi2
1Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.
Abstract:
Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3'-untranslated regions (UTRs) of mRNAs. mRNA 3'-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay. Each RNA binding protein that binds to these cis-acting elements regulates mRNA translation via various mechanisms targeting the mRNA cap structure, the eukaryotic initiation factor 4E (eIF4E)-eIF4G complex, ribosomes, and the poly (A) tail. We also discuss translation-mediated regulation of mRNA fate. [BMB Reports 2017; 50(4): 194-200].
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