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Solvent suppression in DNP enhanced solid state NMR.

Jayasubba Reddy Yarava1, Sachin Rama Chaudhari2, Aaron J Rossini3

  • 1Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|March 14, 2017
PubMed
Summary
This summary is machine-generated.

We demonstrate a method to simplify solid-state NMR spectra by suppressing solvent signals using DNP. This technique enables high-resolution proton-proton correlation experiments for measuring molecular structures in organic solids.

Keywords:
DNPParamagnetic relaxation enhancement (PRE)Relaxation filtersSolid-state NMRSolvent suppression

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Area of Science:

  • Solid-state Nuclear Magnetic Resonance (NMR) spectroscopy
  • Dynamic Nuclear Polarization (DNP) enhancement
  • Materials science

Background:

  • Solid-state NMR spectroscopy is crucial for characterizing materials.
  • Dynamic Nuclear Polarization (DNP) significantly enhances NMR signal sensitivity.
  • Solvent signals in DNP-enhanced solid-state NMR can obscure sample information.

Purpose of the Study:

  • To develop and evaluate methods for suppressing solvent signals in DNP-enhanced solid-state NMR.
  • To enable high-resolution proton-proton correlation experiments in solid samples.
  • To facilitate the measurement of inter-nuclear proximities in organic solids.

Main Methods:

  • Exploiting paramagnetic relaxation enhancement of solvent signals relative to substrates.
  • Utilizing short cross-polarization contact times for selective hyperpolarization transfer.
  • Applying methods to organic microcrystals, surfaces, and frozen solutions.

Main Results:

  • Dramatic simplification of DNP-enhanced solid-state NMR spectra via solvent signal suppression.
  • Successful acquisition of high-resolution DNP-enhanced proton-proton correlation spectra.
  • Demonstrated measurement of inter-nuclear proximities in organic solids.

Conclusions:

  • Solvent signal suppression is an effective strategy for improving DNP-enhanced solid-state NMR.
  • The presented methods enhance spectral resolution and enable detailed structural analysis.
  • This approach advances the application of solid-state NMR for organic materials.